Study, Wilkesbarre to Philly Passenger service.

https://www.masstransitmag.com/rail/new ... k-on-track
I'm honestly not seeing the demand, or viable routes for it, which are competitive with the Turnpike.
There really isn't any way to the city from the south, unless they rebuild the Ashley Planes,
and turn the saucon rail trail into a rail with trail.
That said, I'm sure if R and N would say "sure, we'll make our section 79MPH for passenger, if you pay for it. We'll even give passenger trains priority"

Beyond SEPTA's own jurisdiction for sure. Greyhound does have a daily Philadelphia-Scranton round trip
(depart PHL 11:25 am, arrive 4:15 pm, the return trip leaves Scranton at 5:15 pm, arriving at 9:35 pm).

(See page 41 and 42 of the Greyhound system timetable)