A few additions to the above comments:
1) The "George" was an overnight C&O train Washington - Cincy, with a section from Newport News that joined at Charlottesville (actual jct. point is Gordonsville, VA), and a Louisville section switched out at Ashland, KY. At various times, through cars ran to NYP and Chicago, and there was also a Detroit section (also switched out at Ashland).
2) James Whitcomb Riley was indeed an Indiana poet, and the train of the same name was an NYC, then PC train that ran with a diner and coaches from Cincy to Indianapolis over a line that is now a shortline, thence to Lafayette, IN and Kankakee, and finally into IC's Central Station on IC trackage rights (Detroit trains via Michigan Central also used Central Station until the mid-1960s).
3) Amtrak very quickly combined these two trains into a single through train, which as noted ran as far as NY and BOS at various times. Amtrak also continued the Newport News section for a few years, making it a NYP - NPN train only in the late 1970s.
4) A second section of the train, called the "Mountaineer", ran for a few years in the 1970s. It was switched out at Russell, KY (major C&O yard, not a passenger stop) and ran to Norfolk, VA via the N&W main, passing through Roanoke, Lynchburg, and Petersburg. In 1978 (IIRC) this train was eliminated in favor of a train from WAS to Catlettsburg, KY (new station built by Amtrak, between Huntington and Ashland). The "Hilltopper", as this was known, was a daylight train running from Washington to Petersburg on RF&P and Seaboard System, thence via N&W. It lasted until the cuts of 1980.
5) As to the "Cardinal's" peregrinations through Indiana, here's a concise summary:
- Original route has been described
- First modification was to send the train up the I&F branch from IND to Logansport, then into Chicago on the "Panhandle". CIN - IND route remained same.
- Next change was to the C&O of Indiana, passing through Richmond, Marion, and Muncie, entering Chicago from Griffith, IN over the former Erie and C&WI.
- Following the creation of Conrail, the Erie was abandoned. Train was rerouted from La Crosse, IN to Wellsboro, thence into Chicago on the former B&O and Conrail (from Pine Jct.)
- Meanwhile, in the late 1970s Chessie built Queensgate Yard. This required abandoning the C&O line down Cheviot Hill, so the Cardinal was routed onto the B&O at Cottage Grove, IN and via Hamilton, OH to CIN.
- Finally, with the whole C&O of IN under threat of abandonment, train was re-routed again, this time via the B&O through Hamilton and Cottage Grove all the way to Indianapolis, over the Conrail (former Peoria & Eastern) line from IND to Crawfordsville (which was upgrading for 60 MPH operation), then via a new connection to the former Monon through Lafayette to Munster, IN and via the ex-PRR SC&S (South Chicago & Southern) to Colehour Yard and the CR mainline into Chicago.
- One more re-route occurred in 1994, when CR abandoned a portion of the SC&S. Cardinal now gets onto Grand Trunk at Munster, runs a few miles to Thornton Jct., and turns north on the former C&EI past Yard Center, over the IC at Kensington, and north on the former C&WI (now owned at dispatched by Metra) to 35th Street, where the train uses NS (former CR) trackage to reach Union Station.
Whew!