I recently bought a Windows Vista Computer. I am wondering if it is safe to run MSTS on it. Thank you in advance.
Runs fine on Vista. Train Simulator does a fairly "shallow" install so it doesn't expose itself to many points of failure.
Make sure your graphics drivers are up to the task, of course. If your graphics driver is unstable then so will be your games. Actually, Train Simulator is old enough that it might just run fine on today's integrated graphics chips (which are a lot powerful than the little dinky chips of six years ago!).