Much of this section can be hiked as a trail. From Little Falls to Pattersonville, it's the New York State Canalway Trail, with some small sections where it uses other routes - for instance just west of Fort Plain a house is built on the ROW. Some sections show on their map as proposed and are unimproved, some are a full on bike trail, paved and signed along the route. One bridge is out in Fort Plain. Some rails from sidings are in evidence and at least one depot (Fultonville with it's odd foundation) remains.
The Schoharie Creek bridge may not be passable, not sure what the state is doing there. Two years ago December 5S was still detoured onto the railroad bridge due to damage to the highway bridge next to it, but as of 2013 the road now uses the highway bridge albeit with traffic lights making it single lane. Equipment and barriers are all over the place there.
From Fort Plain to the quarry just east of Amsterdam was only pulled out in 1982, and from there to Pattersonville came out even more recently (CSX I believe removed it).
Little Falls east to Mohawk has some sections where it's largely dissapeared and others where it's still obvious. The highly altered station remains in Mohawk, although it's been moved and I believe 5S actually is routed on some of the ROW. There's a BAR caboose and an old 40' plug door box car as part of the station area, which was a restaurant.