GEVO-12 prime movers are ubiquitous in the freight world. The GE ES44AC and ES44C4 freight locos use it, with those two makes selling a combined 1700+ units to-date rostered on every single Class I in the U.S., Canada, and Mexico. And still in production 13 years after first introduction. It's a flexible enough platform to have Tier 4 variants out now, as well as some alternate-fuel test trials for future variants. There'll be a 50-year parts supply for that prime mover, no doubt. Ditto the GE GEB-15 traction motors, the same ones used for 2 decades on the Genesis P32AC-DM, and the GE 5GMG211 AC alternator. The traction motor replacements when they were first delivered was an installation screw-up, not a component problem.
The only thing custom about the HSP-46 is the component selection/integration, carbody, and software...not the components themselves. It's that systems integration where they're having extended teething problems. Everything else is as generic as it gets. Even if no other railroad buys this make, they will be fully supportable through multiple rebuilds because the component supply is inexhaustible. And you can find second-source vendors to build to the spec if MPI says "no mas". It just may be the same guts in a different carbody with different computers and such, depending on what vendors offer what. We don't have to worry about these becoming dead-end white elephants, and they aren't necessarily consigned to real-world fleet fragmentation if the next loco order has to be something other than a rote HSP-46 refresh. It'll probably be another GEVO-12 / GEB-15 / etc. -derived platform, unless the Chargers/F125's/etc. are so hands-down better an off-shelf buy than another GEVO that systems fragmentation proves too small a concern to worry about.
We also don't have to worry about general build quality making them razorblade fodder at less-than rebuild age like the Brokem coaches because the component selection is tried-and-true. Whether they're long-term worthy is all about success in debugging the integration...particularly the computers. The GP40MC's weren't pieces of crap because the GP40 platform is a piece of crap; Geeps are some of the 20th century's most successful and reliable makes, in both freight and passenger variants. The T just went way too far off-script with the quirky 'MC' computer mods and saddled otherwise bulletproof locos with a "garbage in, garbage out" situation at the control stand. That's the hurdle the HSP's newfangled systems integration has to clear, and stay permanently cleared of without further bug regressions.