on the fiberglass gear cases we use on the emd motors, we have a foam rubber type gasket in the female side of the gearcase [top half] that assist in sealing the 2 halves together. we run a bead of silicone around the female side then bolt them together.. the case splits rarely leak that way, but the pinion seal and the axle seals leak often as they only have a white vinyl/rubber seal..
the ge steel gearcases are entirely sealed with silicone [dow corning 832] except for the axle seals, which are glued to the gearcases with the same silicone. when done right, they will go a long time before they start to leak