EMD would do... what they thought would make a profit. Selling ENGINES to be used in locomotive re-powering competes with their (more profitable) business of selling whole LOCOMOTIVES to replace the off-brand units that would be candidates for repowering. My impression is that-- at least in the 645 era (1966 and later)-- EMD charged prices for new engines that didn't encourage repowering. (Of course, a significant portion of EMD's engine production went for non-rail -- stationary and marine -- applications. Leaving management in a delicate situation: too low a price tag on the engine and rail customers are going to re-engine old Alcos and Baldwins instead of buying new GP38, but too high and you won't sell any engines for tugboats!)
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As for ... weird ... locomotive configurations... Again, they'd do anything if it looked profitable. U.P.'s management was certainly eccentric in wanting 5000(+) horsepower freight diesels in the 1960s, but was a big enough customer (and promised to buy enough copies) that EMD was willing to do significant development work (notably, design a 4-axle truck) to give them DD-35 and DD-40X units. So, if you wanted 12-cylinder engines in F-unit carbodies(*) and A1A trucked geeps badly enough to ask for several dozen of each (and looked like a railroad customer worth cultivating for the future), you could probably have gotten them. I suspect EMD would have been more openminded about such things in the 1940s than later: they actually DID build some E-units with only one engine installed (and a baggage compartment in the rest of the engine room) before WW II, but apparently resisted Amtrak in the 1970s when Amtrak wanted an "E-10."
(*) Export locomotives... demand special engineering, since railways in different countries have different requirements. Locomotives with more or less F-like carbodies but 12-cylinder engines were built for some customers. ... Very few export-model EMD locomotives have been built for North American service, but a few have! So your imagined eccentric and nonconformist railroad president should certainly start by asking to see the export catalogue. ... I'm a GE fan myself, with Vermont ancestors: one of the counterfactual scenarios I sometimes enjoy imagining is one in which the Rutland's light-duty line over a delicate trestle to the islands in the north end of Lake Champlain survives and gets re-equipped with U12B units.
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As for ... weird ... locomotive configurations... Again, they'd do anything if it looked profitable. U.P.'s management was certainly eccentric in wanting 5000(+) horsepower freight diesels in the 1960s, but was a big enough customer (and promised to buy enough copies) that EMD was willing to do significant development work (notably, design a 4-axle truck) to give them DD-35 and DD-40X units. So, if you wanted 12-cylinder engines in F-unit carbodies(*) and A1A trucked geeps badly enough to ask for several dozen of each (and looked like a railroad customer worth cultivating for the future), you could probably have gotten them. I suspect EMD would have been more openminded about such things in the 1940s than later: they actually DID build some E-units with only one engine installed (and a baggage compartment in the rest of the engine room) before WW II, but apparently resisted Amtrak in the 1970s when Amtrak wanted an "E-10."
(*) Export locomotives... demand special engineering, since railways in different countries have different requirements. Locomotives with more or less F-like carbodies but 12-cylinder engines were built for some customers. ... Very few export-model EMD locomotives have been built for North American service, but a few have! So your imagined eccentric and nonconformist railroad president should certainly start by asking to see the export catalogue. ... I'm a GE fan myself, with Vermont ancestors: one of the counterfactual scenarios I sometimes enjoy imagining is one in which the Rutland's light-duty line over a delicate trestle to the islands in the north end of Lake Champlain survives and gets re-equipped with U12B units.